THE CLINICAL-STAGE DRUG BTZ-043 ACCUMULATES IN MURINE TUBERCULOSIS LESIONS AND EFFICIENTLY ACTS AGAINST MYCOBACTERIUM TUBERCULOSIS

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis

Abstract The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark of human tuberculosis (TB).New anti-TB therapies need to effectively penetrate the cellular and necrotic compartments of these lesions and reach sufficient concentrations to eliminate Mtb.BTZ-043 is a novel antibiotic showing good

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The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo

CDKL5 deficiency disorder (CDD) is a rare White Musk fragrance oil X-linked neurodevelopmental disorder that is characterised by early-onset seizures, intellectual disability, gross motor impairment, and autistic-like features.CDD is caused by mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene that encodes a serine/threonine kinase with a

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Case report: retroperitoneal aspergilloma in a patient with rheumatoid arthritis presenting as malignant tumor

Abstract Background Aspergillosis in patients with impaired immunity usually presents with invasive pulmonary infection and dissemination to a variety of organs via hematogenous spread.Aspergilloma in the retroperitoneal cavity is a rare disease with only a few cases reported in the literature.To the best of our knowledge, the present case of a ret

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Traveling Wave Solutions and Infinite-Dimensional Linear Spaces of Multiwave Solutions to Jimbo-Miwa Equation

The traveling wave solutions and multiwave solutions to (3 + 1)-dimensional Jimbo-Miwa equation are investigated in this paper.As a result, besides the exact bounded solitary wave solutions, we obtain the existence of two families of bounded periodic REMARKABLE SILKNESS, LIGHTNESS AND SHINE traveling wave solutions and their implicit formulas by an

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